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First published 1971 (DOST Vol. IV).
This entry has not been updated since then but may contain minor corrections and revisions.

Nepvo, Nepho, n. Also: nepvoy, nepveu, -ew(e, -ieu; nephoy(e, nephu(e, nephow, nephvow, nephwoy, nepheu(e, -ew(e, -ieu, -iew, nephé. [Late ME. nepveu (1454), e.m.E. nepvoy (1562), nephew (1523); varr. of Nevo with -p- introduced appar. after L. nepos.]

1. A nephew.(a) 1456 Hay I. 65/13.
Octovian the nepueu of Julius Cesar 1558 Q. Kennedy Tractive 97.
To my derrest and best beluiffit nepuo Gilbert, Maister of Cassillis c1575 Balfour Pract. 222.
As the nepvoy or neipce 1588 Events Q. Mary & Jas. VI 52.
Nepvo 1608 Lett. & St. P. Jas. VI 127.
My nepvieu the Erle of Abercorne 1609 Elphinstone Fam. Bk. II. 182.
Your kyndlie acceptance of my nepueu 1613 Edinb. B. Rec. VI. 365.
Doctour Craig and his tua nepvewes 1614 Lett. & St. P. Jas. VI 220.
Nepuieu 1615 Highland P. III. 192. 1642 Spalding II. 179.
Prince Rupert, his nepuoy … who quiklie takis journey touardis his vncle, the King of Britane(b) 1524 Douglas Corr. 88.
The King oure soverain lordes nephieu 1525 Acta Conc. Publ. Aff. 230.
As ane kynde and loving eme desiring the weile of his derest nepho 1528 Douglas Corr. 131.
His derrest nepheis persone 1536 Ib. 351.
Nephow 1578 Reg. Privy C. II. 692.
Nepho 1589 Reg. Morton I. 163.
Nepheu 1618 Sutherland Corr. 137.
Nephue 1631 Justiciary Cases I. 187.
The Erll of Bukcleuche, nephoy to Roxburghe c 1640 Maxwell Mem. II. 276.
Nepheue c 1646 Fam. Innes 237.
For my daire nephoye Johne Innes 1651 Edinb. Test. LXV. 209 b.
His nephewes and nyce 1669 Reg. Privy C. 3 Ser. III. 80.
Nephwoy

b. Applied to: the son of one's wife's half-brother; one's niece's husband. 1571 Bann. Trans. 525.
Our nepho Lord Robert Stewart 1653 J. Hope Diary 159.
Overtooke the coach at Heddingtoune where my nephewes Smith and Cochrane … tooke live

2. A grandson. 1526 Douglas Chart. 227.
Archibald now Erle of Angus … nepho, ayr to the said vmquhile Archibald Erle of Angus c1575 Balfour Pract. 224.
Gif ony man deceissis leivand behind him ane nepvoy of his eldest sone alreadie deceist 1589 Reg. Morton II. 319.
William Douglas my nephoy sone … to umquhill Robert Douglas quha was the eldest son and apperand air to me 1597 Skene Verb. S. s.v. Eneya.
The nepuoy lauchfully begotten be the eldest sonne … is onely aire to his gud-schir Id. Reg. Maj. i. 33b.
Gif ane man deceis without sonne or dochter and hes nephois or niecis of ane sonne or of ane dochter Ib. 34. 1622-6 Bisset I. 68/16.
The said King Robertis nepheu or oy … gottin on Mariorie Bruce his dochter sall succeed to the croun Ib. II. 174/19.
The said King Alexander the thrid his nephu a1651 Calderwood I. 9.
Nephew

3. Of females: A grand-daughter; ? also, a niece. 1622-6 Bisset II. 174/11.
Margarett … nepheu and than appeirand air to … King Alexander the thrid 1626 Edinb. Test. LIII. 260.
The said Barbara Forsythe my nephew Ib.
Jonet, Mariorie & Elizabeth Forsythis my nephewis